In the years following World War II, a polio epidemic affected thousands of children in Louisiana, leaving many severely disabled. Her love and concern for these children led the late Elizabeth Miller Robin, a polio victim herself, to establish a rehabilitation hospital exclusively for children. With the financial support and leadership of a special group of community activists, Crippled Children's Hospital, as it was then called, opened in 1955.

For the next 20 years, the hospital served the community as a convalescent and rehabilitation center for physically handicapped children. In 1976, services were added and the hospital expanded to become a full-service hospital for children. It was renamed Children's Hospital. Since that time, the hospital has continued to grow to meet the ever-changing healthcare needs of the community, and to keep pace with advances in pediatric care.

Today, Children's Hospital serves as the Gulf South's leading pediatric medical center, and is dedicated to providing the very best healthcare possible in an atmosphere of love and concern for the whole child.